Bioinformatics and Bioimaging for Signal Pathway analysis and Drug Selection
主 题: Bioinformatics and Bioimaging for Signal Pathway analysis and Drug Selection
报告人: Prof. Xiaobo ZHOU (TMHRI & Cornell Universisty,USA)
时 间: 2010-09-22 15:00-16:00
地 点: 理科一号搂1572
The premise of today’s drug development is that the mechanism of a disease is highly dependent upon underlying signaling and cellular pathways. Such pathways are often composed of complexes of physically interacting genes, proteins, or biochemical activities coordinated by metabolic intermediates, ions, and other small solutes and are investigated with molecular biology approaches in genomics, proteomics, and metabonomics. Nevertheless, the recent declines in the pharmaceutical industry’s revenues indicate such approaches alone may not be adequate in creating successful new drugs. Our observation is that by combining methods of genomics, proteomics, and metabonomics with techniques of bioimaging will systematically provide powerful means to decode or better understand molecular interactions and pathways that lead to disease and potentially generate new insights and indications for drug combination therapy. In this talk, we will describe bioinformatic and bioimaging informatic tool development for signaling pathway reconstruction and multi-scale systematic modeling of response to drug treatment.