Family-based Tests of Imprinting, Linkage and Association
主 题: Family-based Tests of Imprinting, Linkage and Association
报告人: Prof.Wing Kam FUNG (The University of Hong Kong)
时 间: 2008-10-22 上午 10:00 - 11:00
地 点: 理科一号楼 1490
Abstract: Based on case-parents trios, statistics POET, PAT, and TDTI are developed to test for imprinting and linkage/association, respectively. When only one parent is available, the 1-POET, 1-PAT, and 1-TDTI are proposed accordingly. Simulations are conducted to investigate the validity and other properties of these proposed statistics. How to combine case-parents trios and case-parent pairs jointly in testing
for imprinting and linkage/association is addressed. The proposed combined statistics C-PAT and C-TDTI are applicable to the case with more than one affected child
in the family with one parent or both parents.